Insights from PDA Parenteral Packaging 2026: Plunger Stopper Movement Research

Insights from PDA Parenteral Packaging 2026: Plunger Stopper Movement Research
At the 2026 PDA Parenteral Packaging Conference, Smithers expert Charlotte Utting presented research examining how temperature and altitude conditions influence unintended plunger stopper movement (PSM) in pre-filled syringes.

The presentation explored how factors including pressure, temperature, headspace, and stopper friction can affect syringe performance during transportation and distribution. Testing simulated altitude conditions at both 8,000 ft and 16,000 ft equivalent pressures across multiple temperature environments.

Key findings showed that altitude significantly impacts plunger stopper movement, while lower temperatures may reduce movement but do not fully eliminate pressure-related effects. The research highlights the importance of realistic transport simulation to support container closure integrity (CCI) assessments and reduce sterility risks.

The presentation complements the Smithers whitepaper, Variable Temperature Plunger Stopper Movement Testing for Pre-Filled Syringes, which explores the methodology and findings in greater detail.

Reflecting on the experience, Charlotte shared:

Speaking at the conference was incredibly valuable, both professionally and personally. It was great to be able to share our research into plunger stopper movement with a wider audience and engage with people from a range of backgrounds and expertise.

Download the presentation to learn more about the study methodology, findings, and future research opportunities surrounding plunger stopper movement testing.

Smithers-Charlotte-Utting-PDA-Parenteral-2026-Presentation
Smithers-Charlotte-Utting-PDA-Parenteral-2026-Presentation

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